You likely know estrogen as the primary female sex hormone; however, everybody (even men!) generates some level of estrogen.
Estrogen controls the development of secondary sex characteristics in females, regulates the menstrual cycle, and supports conception and pregnancy. Additionally, estrogen can promote blood flow to the brain and have anti-inflammatory effects on the central nervous system.
During your reproductive years, you experience remarkably variable levels of estrogen throughout the month. Estrogen levels spike mid-way through the menstrual cycle prompting the ovaries to release an egg. After ovulation occurs, estrogen declines and eventually drops to its lowest levels of the month just before the onset of menses. It is normal and expected that there will be points in every woman’s cycle when estrogen levels are higher and points when they will be lower.
What Is Estrogen?
The term ‘estrogen’ actually refers to three different hormones: Estrone (E1), Estradiol (E2), and Estriol (E3).
What Is Estrogen Dominance?
This term refers to circumstances in which people develop unhealthy levels of estrogen, a lack of balance between estrogen and progesterone, and/or are not metabolizing/detoxifying thoroughly or properly.
Some things that promote excess amounts of circulating estrogen include:
How Your Body Detoxifies Estrogen
To really understand estrogen and its potential impacts, we also need to discuss the metabolism of estrogen. Estrogen metabolizes in two phases: hydroxylation and methylation. And estrogen metabolism/detoxification can occur via three different metabolic pathways.
This is the most protective pathway and has the lowest risk for developing estrogen-driven health problems. Ideally, 60-80% of the body’s estrone should metabolize down this pathway.
In the first step, hydroxylation, estrone actually becomes more susceptible to oxidation thereby making it more toxic. The second step, methylation, takes these toxins in the body and alters them, thereby readying them for elimination. Methylation involves the transfer of a group of four atoms, known as a methyl group (CH3 – one carbon atom bonded with three hydrogen atoms), to another molecule.
This process occurs in every tissue and cell of the body and changes the structure and function of the molecules. This transformative process helps to convert toxic substances into beneficial substances that support the body’s health and well-being.
This pathway also takes estrone through the process of hydroxylation but phase 2 does not move through the methylation process. Rather, phase 2 along the 16-hydroxy pathway involves a chemical reduction that results in the conversion to estriol. This pathway produces the most estrogenic metabolites; however, it is important to note that these metabolites are still far less estrogenic than estradiol.
This is the dangerous pathway! The process of hydroxylation down the 4-Hydroxy pathway results in the production of a genotoxic metabolite: 4-OH-E1. If 4-OH-E1 is properly methylated during phase 2 metabolism, its potentially harmful effects can be minimized. However, if methylation is at all impaired (potentially due to the presence of specific genetic SNPs), this can be a highly problematic pathway. When 4-OH-E1 starts to build up, it can start to convert to 3,4 Quinones which are known to cause cancer. Given this information, we start to gain some insight into why adequate methylation is critical for overall health!
While each person’s body does have an innate genetic disposition towards the production of estrogens and their preferred metabolic pathways, factors such as diet, exercise, and toxicity also have powerful effects on the way the body manages its estrogen factory!
How to Know if You Have Estrogen Dominance
Here at Hormone Detox Shop, we strongly recommend testing to properly determine your hormone levels. This will result in the most targeted and effective treatment.
The test looks at:
This test is amazing for symptoms such as:
We can test you from your home in most states, from teens to retired, ladies and men. We all have hormones!
Ready to test?
How to Support Estrogen Detox
Tip #1: Detox Estrogen Through Diet
Tip #2: Remove Toxins
Tip #3: Use Supplements
Vital Health and Natural Medicine is committed to ensuring that your privacy is protected. Should we ask you to provide certain information by which you can be identified when using this website, then you can be assured that it will only be used in accordance with this privacy statement.
Vital Health and Natural Medicine may change this policy from time to time by updating this page. You should check this page from time to time to ensure that you are happy with any changes. This policy is effective from January 1st 2012.
We may collect the following information:
What we do with the information we gather
We require this information to understand your needs and provide you with a better service, and in particular for the following reasons:
We are committed to ensuring that your information is secure. In order to prevent unauthorised access or disclosure, we have put in place suitable physical, electronic and managerial procedures to safeguard and secure the information we collect online.
Our Policy for Protecting Your Online Privacy
This website uses Google Analytics to help analyse how users use the site. The tool uses “cookies,” which are text files placed on your computer, to collect standard Internet log information and visitor behaviour information in an anonymous form. The information generated by the cookie about your use of the website (including IP address) is transmitted to Google. This information is then used to evaluate visitors of the website and to compile statistical reports on website activity for MyVitalHealthSolutions.com.au.
We will never (and will not allow any third party to) use the statistical analytics tool to track or to collect any Personally Identifiable Information (PII) of visitors to our site. Google will not associate your IP address with any other data held by Google. Neither we nor Google will link, or seek to link, an IP address with the identity of a computer user. We will not associate any data gathered from this site with any Personally Identifiable Information from any source, unless you explicitly submit that information via a fill-in form on our website.
A cookie is a small file which asks permission to be placed on your computer’s hard drive. Once you agree, the file is added and the cookie helps analyse web traffic or lets you know when you visit a particular site. Cookies allow web applications to respond to you as an individual. The web application can tailor its operations to your needs, likes and dislikes by gathering and remembering information about your preferences.
We use traffic log cookies to identify which pages are being used. This helps us analyse data about webpage traffic and improve our website in order to tailor it to customer needs. We only use this information for statistical analysis purposes and then the data is removed from the system.
Overall, cookies help us provide you with a better website by enabling us to monitor which pages you find useful and which you do not. A cookie in no way gives us access to your computer or any information about you, other than the data you choose to share with us.
You can choose to accept or decline cookies. Most web browsers automatically accept cookies, but you can usually modify your browser setting to decline cookies if you prefer. This may prevent you from taking full advantage of the website.
Links to other websites
Our website may contain links to other websites of interest. However, once you have used these links to leave our site, you should note that we do not have any control over that other website. Therefore, we cannot be responsible for the protection and privacy of any information which you provide whilst visiting such sites and such sites are not governed by this privacy statement. You should exercise caution and look at the privacy statement applicable to the website in question.
Controlling your personal information
You may choose to restrict the collection or use of your personal information in the following ways:
We will not sell, distribute or lease your personal information to third parties unless we have your permission or are required by law to do so (we hate spam as much as you do… probably more). We may use your personal information to send you promotional information about third parties which we think you may find interesting if you tell us that you wish this to happen.
You may request details of personal information which we hold about you under the Data Protection Act 1998. A small fee will be payable. If you would like a copy of the information held on you please write to firstname.lastname@example.org
If you believe that any information we are holding on you is incorrect or incomplete, please write to or email us as soon as possible at the above address. We will promptly correct any information found to be incorrect.