METABOLIC ORGANIC ACIDS TEST

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The Nutripath Comprehensive Profile provides a view into the body’s cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the analytes are markers of intestinal bacterial or yeast overgrowth.

DESCRIPTION: This test measures four critical areas of metabolism: gastrointestinal function and dysbiosis markers, cellular and mitochondrial energy metabolites, neurotransmitter metabolites, and functionally important organic acid metabolites of amino acids. The reference ranges for this test apply to children (2-12 yrs) and adults.
The Organic Acids Test provides a view into the body’s cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks or problems with detoxification, gut dysbiosis, or oxidative stress that can be treated nutritionally allows for individual tailoring of interventions. Targeted treatment can help maximize patient responses and lead to improved patient outcomes.

Why use an organic acid test?

Organic acids are metabolic intermediates produced in pathways of central energy production, detoxification, neurotransmitter breakdown, and intestinal microbial activity. Accumulation of specific organic acids in urine often signals a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. Testing for organic acids helps reveal activity and changes at the metabolic level, helping practitioners discover hidden issues and pinpoint where therapeutic focus is needed.

The Nutripath Profile provides important information in the areas of:
• Vitamin and mineral insufficiencies
• Amino acid insufficiencies like carnitine and N-acetyl cysteine (NAC)
• Oxidative damage and antioxidant sufficiency markers
• Indicators to assess detoxification sufficiency
• The best functional markers of B-complex deficiency
• Neurotransmitter metabolites to assess central nervous system (CNS) function
• Mitochondrial energy production assessment via citric acid cycle components
• Methylation sufficiency status
• Lipoic acid and CoQ10 sufficiency markers
• Specific dysbiosis markers for bacterial and yeast overgrowth

The ORGANIC ACIDS TEST can provide important information for treating certain conditions, including:
• Fatigue
• Sleep abnormalities
• Mood changes
• Blood sugar dysregulation
• Weight gain
• Nausea
• Multiple chemical sensitivity
• Bloating
• Distention
• Joint pain
• Gas
• Reflux
• Autoimmune disorders
• Dermatitis
• Depression
• Anxiety
• Cancer
• Inflammation
• Headaches
• Early aging

Analytes

FATTY ACID METABOLISM
Adipate
Suberate
Ethylmalonate
CARBOHYDRATE METABOLISM
Pyruvate
Beta-Hydroxybutyrate
ENERGY PRODUCTION (CITRIC ACID CYCLE)
Citrate
cis-Aconitate
Isocitrate
Alpha-Ketoglutarate
Succinate
Fumarate
Malate
Hydroxymethylglutarate
B-COMPLEX VITAMIN MARKERS
Alpha-Ketoisovalerate
Alpha-Ketoisocaproate
Alpha-Keto-Beta-Methylvalerate
Xanthurenate
Beta-Hydroxyisovalerate
METHYLATION COFACTOR MARKERS
Methylmalonate
Formiminoglutamate
NEUROTRANSMITTER METABOLISM MARKERS
Vanilmandelate
Homvanillate
5-hydroxyindoleacetate
Kynurenate
Quinolinate
Picolinate*
OXIDATIVE DAMAGE AND ANTIOXIDANT MARKERS
p-Hydroxyphenyllactate

DETOXIFICATON INDICATORS
2-Methylhippurate
Orotate
Glucarate
Alpha-Hydroxybutyrate
Pyroglutamate
Sulfate
BACTERIAL-GENERAL
Benzoate
Hippurate
Phenylacetate
Phenylpropionate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
Tricarballylate
CLOSTRIDIAL SPECIES
3,4 Dihydroxyphenylpropionate
YEAST/FUNGAL
D-Arabinitol*